Diabetologie und Stoffwechsel 2021; 16(S 01): S34
DOI: 10.1055/s-0041-1727380
04. Grundlagenforschung Adipositas/Metabolisches Syndrom

Role of Nicotinuric acid in metabolic inflammation and type 2 diabetes

J Brandes
1   Department of Medicine 1, University of Kiel, Germany, Division of Endocrinology, Diabetes and Clinical Nutrition, Kiel, Germany
,
T Demetrowitsch
2   Institute of Human Nutrition and Food Science, University of Kiel, Germany, Division of food technology, Kiel, Germany
,
I Suhrkamp
3   Department of Dermatology, University Medical Centre Schleswig Holstein, Campus Kiel, Germany, Centre of inflammatory skin diseases, Kiel, Germany
,
D Pohlschneider
1   Department of Medicine 1, University of Kiel, Germany, Division of Endocrinology, Diabetes and Clinical Nutrition, Kiel, Germany
,
K Schlicht
1   Department of Medicine 1, University of Kiel, Germany, Division of Endocrinology, Diabetes and Clinical Nutrition, Kiel, Germany
,
F Brix
2   Institute of Human Nutrition and Food Science, University of Kiel, Germany, Division of food technology, Kiel, Germany
,
J Jensen-Kroll
2   Institute of Human Nutrition and Food Science, University of Kiel, Germany, Division of food technology, Kiel, Germany
,
K Hartmann
1   Department of Medicine 1, University of Kiel, Germany, Division of Endocrinology, Diabetes and Clinical Nutrition, Kiel, Germany
,
K Türk
1   Department of Medicine 1, University of Kiel, Germany, Division of Endocrinology, Diabetes and Clinical Nutrition, Kiel, Germany
,
S Schreiber
1   Department of Medicine 1, University of Kiel, Germany, Division of Endocrinology, Diabetes and Clinical Nutrition, Kiel, Germany
,
U Mrowietz
3   Department of Dermatology, University Medical Centre Schleswig Holstein, Campus Kiel, Germany, Centre of inflammatory skin diseases, Kiel, Germany
,
K Schwarz
2   Institute of Human Nutrition and Food Science, University of Kiel, Germany, Division of food technology, Kiel, Germany
,
M Laudes
1   Department of Medicine 1, University of Kiel, Germany, Division of Endocrinology, Diabetes and Clinical Nutrition, Kiel, Germany
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    Introduction Aromatic amino acids, especially tryptophan (Trp), are reported to be important biomarkers to identify human subjects at high risk for type 2 diabetes (T2D). Moreover, some metabolites of the Niacin-pathway, like nicotinuric acid (NUA), exhibit pro-inflammatory capacity by promoting polarization of M2 in M1-macrophages. The aim of the study was to use non-targeted metabolomics analyses to further characterize the Trp / niacin- metabolism in metabolic inflammation.

    Patients and methods A sub-cohort of 600 male and female subjects (age 23-89) from the Food-Chain-Plus cohort (FoCus) was selected. The subjects were stratified in 200 healthy, 200 prediabetes (defined by impaired fasting glucose = IFG) and 200 patients of T2 D. Trp - and niacin metabolites were measured by FT-ICR-MS. The data evaluation was conducted with MetaboScape 4.0 (Bruker, Germany) and statistically analyzed by SPSS-Software (IMB, Germany).

    Results Trp- metabolites kynurenine, anthranilic acid and Trp itself were found in sub-cohort samples. In addition, 18 further compounds of niacin metabolism, like NUA, were identified. Investigation showed a significant difference in intensity between the groups, which was particularly notable in NUA. While groups of IFG and T2 D did not show significant differences in intensity among each other, they both exhibited significant higher intensities of NUA compared to controls (p < 0,001 for both).

    Conclusion This investigation indicates that NUA might be linked to metabolic inflammation. Remarkable intensity differences of NUA between healthy subjects and persons with IFG or T2 D suggest that increasing intensity of this metabolite provides a shift from M2 to M1-macrophages and therefore reinforces low-grade inflammation.


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    Interessenskonflikt

    no conflict of interest

    Publication History

    Article published online:
    06 May 2021

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