Lee Y,
Silverman RB.
*
Northwestern University, Evanston, USA
Solid-Phase Syntheses of
N
ω-Propylarginine-Containing Dipeptides, Dipeptide Esters, and Dipeptide Amides.
Synthesis 1999; 1495-1499
DOI:
10.1055/s-1999-6077
Key words
solid-phase synthesis - arginine - propylpyrazolecarboxamidine - guanylating agent
- dipeptides
Significance
N
ω-Substituted arginine-containing peptides have a significant role in the endogenous
synthesis of nitric oxide (NO). In 1999, Lee and Silverman developed an efficient
method for the solid-phase synthesis of N
ω-propylarginine-containing dipeptides.
Comment
N-Propyl-1H-pyrazole-1-carboxamidine is an efficient guanylating agent for the synthesis of
N
ω-propylarginine-containing dipeptides in moderate yields. The method can be used for
the synthesis of peptides having an N
ω-propylarginine at either the N- or the C-terminus.
