N-Propyl-1H-pyrazole-1-carboximidamide for the Synthesis of N ^ω-Propylarginine-Containing Dipeptides

Key words

solid-phase synthesis - arginine - propylpyrazolecarboxamidine­ - guanylating agent - dipeptides

Significance

N ^ω-Substituted arginine-containing peptides have a significant role in the endogenous synthesis of nitric oxide (NO). In 1999, Lee and Silverman­ developed an efficient method for the solid-phase synthesis of N ^ω-propylarginine-containing dipeptides.

Comment

N-Propyl-1H-pyrazole-1-carbox­amidine is an efficient guanylating agent for the synthesis of N ^ω-propylarginine-containing dipeptides in moderate yields. The method can be used for the synthesis of peptides having an N ^ω-propyl­arginine at either the N- or the C-terminus.

Publication History

Article published online:
17 December 2021