DOI: 10.1055/s-00000131

Synfacts

Issue 01 · Volume 18 · January 2022 DOI: 10.1055/s-011-52578

Synform

A1
Zanda, Matteo: SYNFORM ISSUE 2022/01

Synthesis of Natural Products and Potential Drugs

z0001
All PDFs of this category
0001
Synthesis of (+)-Cyclobutastellettolide B
0002
Synthesis of MK-4688
0003
Synthesis of Reldesemtiv
0004
Total Synthesis of (+)-Toxicodenane A
0005
Synthesis of (–)-Taxol
0006
Synthesis of Dengue Virus Inhibitor JNJ-A07
0007
Synthesis of GDC-4379
0008
Total Synthesis of (–)-Cephanolide A
0009
Total Synthesis of (+)-Pileamartine A
0010
Synthesis of BMS-986278
0011
Synthesis of (–)-Chrodrimanin C and (–)-Verruculide A
0012
Total Synthesis of (±)-Muscone

Synthesis of Heterocycles

z0013
All PDFs of this category
0013
Synthesis of Halogenated Azidopyridines
0014
Pd(II)-Catalyzed Synthesis of Functionalized Dihydrobenzoxazines and a Functionalized Tricyclic System
0015
Machine-Learning-Based Approach to Expanding SAR Exploration
0016
Single-Electron Reduction of Sulfonium Salts for the Generation of Nonstabilized Alkyl Radicals
0017
Regioselective Late-Stage Alkylation of Complex Molecules
0018
Sulfonium-Salt Based Trifluoromethylating Reagent Permits Multiple Reactivity Paradigms
0019
One-Step Synthesis of Pyrazolo[1,5-a]pyrimidines by a Copper-Catalyzed Dehydrogenation/[3+3] Annulation
0020
Gold-Catalyzed Synthesis of Versatile Heterospirocycles
0021
Synthesis of Seven-Membered N,O-Heterocycles by Using a Palladium(sulfoxide) White-Type Catalyst
0022
Indole Synthesis through Reductive Cyclization of 2-Nitrostyrenes with Phenyl Formate as a CO Surrogate

Synthesis of Materials and Unnatural Products

z0023
All PDFs of this category
0023
Cavitands with Controllable Side Walls
0024
Stairway to Thienoacenes
0025
Molecular Bannisters
0026
Remarkably Stable Boron-Containing Organic Diradicaloids
0027
Double the Heterohelicene Fun with Borons and Nitrogens
0028
Well-Defined SixGeyClusters
0029
Versatile Aryl Halide Hydroxylation
0030
Double π-Extended Helicenes via an Unsymmetrical Twofold Scholl Cyclization
0031
Synthesis of Multisubstituted Imidazolo[4,5-d]pyridazine Fused Ring System
0032
Half-Fused Condensation Polymers
0033
Synthesis of a Rigid Nanopillar
0034
Synthesis of α-Aryl Azahelicene

Metals in Synthesis

z0035
All PDFs of this category
0035
Synthesis of Sulfinamides, Sulfonimidamides, and Sulfonamides: A One-Pot Procedure to Rule them All
0036
Tied Together: meta-Selective C–H Alkenylation of Pyridines Enabled by a Bifunctional NHC Ligand
0037
Enantioselective Cobalt-Catalyzed Alkene Hydroalkylation
0038
Manganese Enables the Dehydrogenative Silylation of Alkenes Instead of Simple Hydrosilylation
0039
Rhodium(III)-Catalyzed Diastereoselective Oxyamination of 1,3-Dienes
0040
Synthesis of Diarylamines by Reductive Cross-Coupling of Nitroarenes and Aryl Boronic Acids
0041
A Dual Ni/Cu Catalytic System for the Linear Selective Hydroalkylation of Vinyl Arenes
0042
Quantitative Carbon Isotope Labeling of Carboxylic Acids
0043
Cobalt Does What Nickel Cannot Do: Cobalt-Catalyzed Enantiospecific Vinylation of Allylic Alcohols
0044
Rhodium-Catalyzed [2+2+1] Hydrative Annulation of 1,6-Enynes and Terminal Alkynes
0045
Linking Carbon and Silicon Electrophiles: C(sp3)–Si Cross-Coupling of Alkyl Bromides and Vinyl Chlorosilanes
0046
Catalytic 1,2-Difunctionalization of Alkenes with Alkyl Iodides and Isocyanides under Visible-Light Irradiation
0047
The Mastering of Triplets: A Triplet-Energy-Transfer Strategy for the Synthesis of 1- and 2-Azetines
0048
Photoredox-Catalyzed Decarboxylative Cross-Coupling of C–O Bonds via a Carbocation
0049
Gold-Catalyzed Asymmetric [3,3]-Sigmatropic Rearrangement of Vinyl Sulfoxides and Propargyl Silane
0050
Esters in a Squeeze: A Bifunctional Copper Catalyst Effects the Hydrogenation of Esters to Alcohols
0051
Nickel-Catalyzed Hydrocarboxylation and Enantioselective Transfer Hydrogenation of Alkynes
0052
Nickel-Catalyzed Enantioselective Allylic Alkylation of Phosphinates
0053
Enantioselective Iron-Catalyzed Formal [4+2] Cycloaddition
0054
It’s All About Boron: Access to Boron-Stereogenic Compounds by a Desymmetrizing Click Reaction
0055
Back to the Carbonyl: Iron-Catalyzed Degradation of Alcohols by C–C Bond Cleavage
0056
Palladium-Catalyzed Arylative Ring Expansion of Fused Bicyclic Vinyl Cyclopropanes
0057
Anti-Markovnikov Hydroamination of Alkenes Enabled by Dual Phospine/Photoredox Catalysis
0058
Enantioselective Difunctionalization of 1,3-Enynes via Palladium-Catalyzed Tandem Coupling/Suzuki Cascade
0059
You Only React Twice: Synthesis of 2-Iminothietanes by Twofold Methylene Insertion to Isothiocyanates
0060
Palladium- and Copper-Catalyzed Synthesis of 1,3-Dienes
0061
Synthesis of Enantioenriched Morpholines via Rhodium-Catalyzed Asymmetric Hydrogenation
0062
The Bönnemann–Wakatsuki Pyridine Synthesis
0063
Gold(III)-Catalyzed Hydration of Alkynes

Polymer-Supported Synthesis

z0065
All PDFs of this category
0065
Photoinduced Cross-Coupling with a Supported Iridium–Nickel Bimetallic Catalyst
0066
Polyoxomolybdate-Based Chromium(III) Catalyst for the Synthesis of Disulfides from Boronic Acids
0067
Humic-Acid-Supported Platinum Single Atoms for Regioselective Alkene Hydrosilylation
0068
Olefination of Aryl Aldehydes with Ethyl Diazoacetate on a Carbon-Supported Co/Cu Bimetal Catalyst
0069
C–H Alkylation and Arylation of 2-Picolinamides on an Immobilized Bipyridine–Manganese Complex
0070
C(sp2)–H Halogenation and Arylation on a Heterogeneous Polymeric NHC–Palladium Catalyst
0071
Covalent Organic Framework Catalysts for Carboxylation of Terminal Alkynes
0072
Synthesis of Quinoline-3-carbonitriles on a Cobalt Ferrate–Graphene Quantum Dot Nanocomposite
0073
Suzuki–Miyaura Cross-Coupling by a Pd–Schiff Base Complex Immobilized on a Hypercrosslinked Polymer
0074
A Recyclable Alternative to DMF Solvent for Syntheses of Benzylic Azides and 1,2,3-Triazoles

Organo- and Biocatalysis

z0075
All PDFs of this category
0075
Efficient Synthesis of Molnupiravir by a Biocatalytic Cascade Involving a Phosphate-Recycling Strategy
0076
Directed-Evolution-Modified Class I Aldolase Catalyzes Asymmetric Michael Addition of Nitromethane to Enals
0077
Enzyme-Bound Iminium Ion Intermediate for Cyclopropanation of Cinnamaldehydes
0078
Visible-Light-Driven Organocatalytic Hydrosilylation to form Polycarbosilanes with Tunable Structures
0079
Biocatalyst Permits Enantioselective Amine Insertion into Lactone Carbenes through Dual Activation
0080
Visible-Light-Mediated Decarboxylative Conjugate Olefination
0081
Asymmetric Cyclopropanation of (E)-Chalcones with Benzyl Bromides by Organoselenium Catalysis
0082
Chiral Brønsted Acid-Catalyzed Dearomatization Reactions by Direct Activation of Ynamides
0083
Asymmetric Photoinduced 1,4-Selective Allylation of α,β-Unsaturated Aldehydes through Organocatalysis
0084
Phosphine-Catalyzed Three-Component Alkyne Hydrovinylation

Chemistry in Medicine and Biology

z0085
All PDFs of this category
0085
The Next Generation Lincosamide: Iboxamycin
0086
BromoTag – A ‘Bump-and-Hole’ PROTAC System
0087
Biosynthetic Glycan Labeling
0088
Development of a Selective PI3Kγ Inhibitor
0089
Aristoquinoline – A nAChRally Occurring Antagonist
0090
Glutathione-Sensitive Imaging and Targeted Drug Delivery
0091
Orally Dosed Lipid-Lowering Peptide
0092
Expanding the Toolbox of Synthetic Genetics
0093
Photoswitchable Anion Carriers
0094
Umibecestat, A Highly Selective β‑Secretase (BACE1) Inhibitor
0095
Presaccharothriolide Z, an (E)-Enone-Containing, 10-Membered Macrolactone
0096
No Strain-No Gain: Adducts of Strain-Release Povarov Reaction Against Multidrug-Resistant Persister Bacteria
0097
Hygromycin A Finds a New Purpose

Peptide Chemistry

z0099
All PDFs of this category
0099
Photochemical Functionalization of Peptides on a Solid Support
0100
C–H Activation/Lossen Rearrangement/Annulation to Access Trifluoromethylated Amino Acids
0101
Palladium-Catalyzed Multiple S-Arylation for the Synthesis of Macrocyclic Peptides
0102
Nickel-Catalyzed Alkenylation and Arylation of α-C-Tosyl Peptides with C(sp2) Triflates/Halides
0103
Electrochemical Synthesis of Amino Acid Amides Catalyzed by TEMPO
0104
Palladium-Catalyzed Olefination of Tryptophan Residues in Peptides
0105
Organocatalytic Synthesis of Chiral α-Halo-α-Aryl-β2,2-Amino Acid Derivatives
0106
Molybdenum-Catalyzed Indane-Based Amino Acid/Peptide Synthesis
0107
Electrochemical Synthesis of N-Boc-α-Amino Acids
0108
Racemization-Free Dipeptide Synthesis by Using a Chloro(triphenyl)phosphonium Intermediate
0109
N-Propyl-1H-pyrazole-1-carboximidamide for the Synthesis of Nω-Propylarginine-Containing Dipeptides

Flow Chemistry

z0111
All PDFs of this category
0111
Enantioselective Scandium Catalyzed C–C Bond-Forming Reactions in Continuous Flow
0112
A Scalable Flow System for the Diels–Alder Reaction of Phenylacetylenes with Dicyclopentadiene
0113
Flow-Type C–H Amidation to Afford α-Amino Acid Derivatives
0114
Electrochemical Cross-Coupling of Arenes under Flow Conditions