Non-Pharmacological Treatments of Neuropsychiatric Symptoms in Mild Cognitive Impairment

Kristina Thurin; Kirk Daffner; Seth Gale; Nancy J. Donovan; Juan Carlos Urizar

doi:10.1055/s-0042-1742486

Seminars in Neurology, Table of Contents

Semin Neurol 2022; 42(02): 192-203
DOI: 10.1055/s-0042-1742486

Review Article

Non-Pharmacological Treatments of Neuropsychiatric Symptoms in Mild Cognitive Impairment

Kristina Thurin

¹Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, Ohio

,

Kirk Daffner

²Division of Cognitive and Behavioral Neurology, Department of Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

,

Seth Gale

³Division of Cognitive and Behavioral Neurology, Department of Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

,

Nancy J. Donovan

⁴Division of Geriatric Psychiatry, Departments of Psychiatry and Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

,

Juan Carlos Urizar

⁵Division of Geriatric Psychiatry, Departments of Psychiatry and Neurology, Brigham andWomen's Hospital, Harvard Medical School, Boston, Massachusetts

› Author Affiliations

Abstract

Mild cognitive impairment (MCI) is a syndrome defined by objective cognitive deficits that do not impact functional independence. Individuals with MCI develop dementia at an annual rate of 10 to 15%. Neuropsychiatric symptoms (NPS) are common non-cognitive features of neurocognitive disorders and have a major impact on the wellbeing and quality of life of affected individuals and their families. Non-pharmacological interventions for NPS are considered the first-line treatment because of the limited efficacy and side-effect potential of current pharmacological agents. This article summarizes the literature on non-pharmacological treatments for NPS in MCI. The limited number of studies specific to individuals with MCI and its various etiologies, as well as the overall heterogeneity of research design and methodologies, make the evidence base inconclusive. Nevertheless, some studies support psychosocial interventions aimed at individuals with MCI and their caregivers.

Keywords

mild cognitive impairment - neuropsychiatric symptoms - non-pharmacologic interventions - neuropsychiatry - behavioral neurology

Full Text

References

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