Dedicated to Dr. Peter Ehlers on the occasion of his 40th birthday
The present article presents a personal account on the synthesis of heterocycles by the combination of regioselective Pd-catalyzed cross-coupling reactions of polyhalogenated heterocycles, i.e., Suzuki–Miyaura and Sonogashira reactions, with alkyne-carbonyl-metathesis (ACM) reactions. The products, which show interesting optical, electronic or medicinal properties, are not readily available by other methods.
Key words
catalysis - cross-coupling - metathesis - heterocycles - palladium - regioselectivity - 1 Introduction - 2 6-Azaullazines and Pyrrolo[1,2-
a]naphthyridines - 3 Dibenzoacridines - 4 Azapyrenes - 5 Naphthothiophenes - 6 Imidazo[1,2-
a]benzoazepines - 7 Dibenzotropones - 8 Conclusions