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Synlett 2024; 35(17): 2027-2031
DOI: 10.1055/s-0042-1751579
DOI: 10.1055/s-0042-1751579
letter
TfOH-Catalyzed Facile Access for One-Pot Synthesis of β-Acylamino Ketones by Avoiding the Usage of Acetyl Chloride
Abstract
We have developed a TfOH-catalyzed, highly efficient protocol for the synthesis of biologically active β-acylamino ketones from aldehyde, ketone, and nitrile by avoiding the use of acetyl chloride. The reaction proceeds through a sequential aldol reaction followed by a nucleophilic attack of nitrile and hydrolysis of nitrile in one pot. The attractive features of this tandem process are mild reaction conditions, high atom economy, broad substrate scope with 51–87% yield, gram-scale reaction, and ease of operation.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1751579.
- Supporting Information
Publication History
Received: 23 November 2023
Accepted after revision: 18 March 2024
Article published online:
28 March 2024
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