Zhao M,
Chen M,
Wang T,
Yang S,
Peng Q,
*,
Tang P.
*
Nankai University, Tianjin, P. R. of China
Fluorocarbonylation Via Palladium/Phosphine Synergistic Catalysis.
Nat. Commun. 2023;
14: 4583
DOI:
10.1038/s41467-023-40180-6
Key words
acyl fluorides - fluorocarbonylation - palladium catalysis - phosphine catalysis - synergistic catalysis
Significance
A novel method for the synthesis of acyl fluorides from potassium (het)aryl/alkyl trifluoroborates is reported. The trifluoromethyl arylsulfonate (TFMS) serves as source of the in situ generated hazardous COF2 gas.
Comment
Detailed mechanistic studies including DFT calculations support the proposed mechanism. The dual role of the phosphine is noteworthy, acting as both organocatalyst and ligand of the palladium redox cycle.
