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Synfacts 2023; 19(01): 0037
DOI: 10.1055/s-0042-1753184
DOI: 10.1055/s-0042-1753184
Metals in Synthesis
Palladium-Catalyzed Cross-Coupling of Aryl Halides with Carboxylic Acids by Photoinduced Reductive Elimination

Significance
A palladium-catalyzed cross-coupling of aryl halides with carboxylic acids under visible-light irradiation is disclosed. The reaction affords aryl esters in moderate to good yields. Key to success is the design and use of a non-innocent phosphinoacridine ligand.
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Comment
Experimental mechanistic studies revealed that the palladium(II) species undergoes a photoinduced reductive elimination, which is promoted by a metal-to-ligand charge transfer (MLCT) in the excited state.
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Publication History
Article published online:
16 December 2022
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