DOI: 10.1055/s-00000131

Synfacts

Issue 01 · Volume 19 · January 2023 DOI: 10.1055/s-012-56110

Synform

A1
Zanda, Matteo: SYNFORM ISSUE 2023/01

Synthesis of Natural Products

z0001
All PDFs of this category
0001
Total Synthesis of (±)-Daphgraciline
0002
Synthesis of (+)-Dysiherbols A and D
0003
Synthesis of (–)-Gedunin
0004
Total Synthesis of (+)-Gilbertine
0005
Total Synthesis of (±)-Psammaplysin A
0006
Synthesis and Structural Revision of (±)-6,11-Epoxyisodaucane
0007
Total Synthesis of Pagodane

Synthesis of Heterocycles

z0009
All PDFs of this category
0009
Synthesis and Biological Activity of Bicyclic Nitroimidazole Derivatives
0010
Synthesis and Characterization of Spiro-Tetrahydro­tetrazines as Energetic Materials
0011
Preparation of 4-Iodo-1-tosylpyrazoles via Iodocyclization of N-Propargyl-N′-tosylhydrazines
0012
Rh(I)-Catalyzed Synthesis of 3-Substituted Oxindoles
0013
One-Pot Synthesis of N-Aryl Tetrahydroquinolines
0014
Iron-Catalyzed Stereo-Convergent Cyclization with E/Z-Mixed Internal Olefines
0015
A Grignard-Free 1,2-Arylation of Isatins
0016
Nickel-Catalyzed Synthesis of chiral N-Heterocycles via C(sp3)–H Activation of Formamides
0017
An Aza-Baeyer–Villiger Reaction for Nitrogen Insertion into Cyclobutanones
0018
Decarboxylative Asymmetric Allylic Alkylation for the Synthesis of α‑Difunctionalized Cyclic Sulfones
0019
Multicomponent Reaction for the Synthesis of Quinoxalin-2-Thiones and Quinoxalines
0020
Catalyst-Free Synthesis of CF3-Containing 2-Pyrazolines via [3+2] Cycloadditions
0021
Pd-Catalyzed Suzuki Coupling of Nitroarenes and Heteroarylboronate Esters

Synthesis of Materials and Unnatural Products

z0023
All PDFs of this category
0023
Cyclopropane-fused Dehydro[10]annulene
0024
Fused Heteroaromatics via Double C–F Activation
0025
Large Arylene Vinylene Polymers Stitched by Rhodium
0026
Linear Ladder-Type S,N-Heteroacenes
0027
4-Organoselenyl Quinolines
0028
A Cubic Electron Catcher
0029
Phosphaalkene Metathesis to Tetraaryl Olefins
0030
Cyclopolymerization towards Bicyclic Polyacetylenes
0031
[1,4]Diazocine with Application as Chiral Ligand
0032
From Vinyl Azides to Phenanthridines
0033
Twisted Armchair-Edged Graphene Nanoribbons
0034
Metal-Free Benzylic C–O Cyclization

Metals in Synthesis

z0035
All PDFs of this category
0035
Selective Cyanation of Benzylic C(sp3)–H Bonds Using Photoelectrochemical Asymmetric Catalysis
0036
The Kochi–Salomon [2+2] Photocycloaddition of Amine-Containing Dienes under Aqueous Conditions
0037
Palladium-Catalyzed Cross-Coupling of Aryl Halides with Carboxylic Acids by Photoinduced Reductive Elimination
0038
Rh(II)-Catalyzed Arylation/Allylation of Diazo Esters
0039
Nickel-Catalyzed Dicarbofunctionalization of Olefins
0040
Directed Addition of Nitroalkanes Across Unactivated Olefins via Palladium(II) Catalysis
0041
Shining Blue Light on the Palladium-Catalyzed Carbo-iodination of Alkenes Leads to a Radical Mechanism
0042
Palladium(0)-Catalyzed Carbonylative Formation of Acyl-DMAP Salts from Organotriflates
0043
Synthesis of Spirocyclic and Bis-Indolinones via Palladium-Catalyzed Carbonylation Reactions
0044
Regio- and Enantioselective Alkylation of Pyridinium Ions in C2 or C4 Position
0045
Dual Iron/Photoredox-Catalyzed 1,2-Arylchlorination of Vinylboronic Esters via In Situ Generated Aryl Radicals
0046
Nickel-Catalyzed Enantioselective Hydrocarbo- and Dicarbofunctionalization of Alkenes
0047
Z-Selective Olefin Metathesis by Combining Grubbs II with a Photoisomerization Catalyst
0048
Enantioselective Three-Component 1,2-Oxyalkylation of Conjugated Dienes under Copper Catalysis
0049
Palladium(0) α-Arylation of Enones Using Aryltriflates via a Morita–Baylis–Hillman Approach
0050
Nucleophilic Ring Opening of Arylcyclopropanes under Photoredox Catalysis
0051
Ni/Photoredox-Catalyzed Ring-Opening/Alkylation of Aziridines
0052
Regiodivergent Disilylation of Arylacetylenes Using Cobalt Catalysis in a One-Pot, Two-Step Fashion
0053
Photocatalytic Decarboxylative C–H Alkylation of Pyridines Under Oxidant-Free Conditions
0054
Synthesis of Fluorinated Chromanes via Palladium-Based Dyotropic Rearrangement
0055
Stereospecific Cross-Coupling of Cyclopropyl Zincates under Dinuclear Palladium(I) Catalysis
0056
Enantioselecitve Allylation/Retro-Claisen Cascade
0057
Bimetallic-Catalyzed Asymmetric C2-Selective C–H Alkylation of Pyridines with 1,3-Dienes
0058
Modular Synthesis of Esters Using Unactivated Alkyl Chlorides, CO, Alcohols and Rhodium Catalysis
0059
The Murai Reaction: ortho-Directed Ruthenium-Catalyzed C–H Alkylation of Aromatic Ketones
0060
Regioselective N-Allylation of Azoles Using Dual Palladium(0)–Organoboron Catalysis and Allyl Alcohols
0061
Intramolecular Nucleopalladation/Carbonylation of Alcohol-Tethered Alkenes

Polymer-Supported Synthesis

z0063
All PDFs of this category
0063
Z-Selective Semi-Hydrogenation of Alkynes by a Cobalt-Melamine Catalyst Supported on SiO2
0064
Aerobic Oxidation of Sulfides by Zr-Based Porphyrin MOFs Using HOOC-TEMPO Under Red LED Irradiation
0065
Photocatalytic Reductive Dimerization of Aryl Bromides Using Water as a Reductant
0066
Fluorination of Acyl Chlorides Promoted by a Single-Atom Cobalt Catalyst
0067
Zn-Catalyzed Aerobic Oxidation of Alcohols Under Solvent-Free and Blue LED Irradiation Conditions
0068
Synthesis of a Covalent Organic Framework through a Sunlight Photocatalytic Reaction
0069
α-Alkylation of Ketones with Alcohols Using a MgO-Codeposited Mn Catalyst Supported on Al2O3
0070
Suzuki–Miyaura Coupling by Pd Polyaniline Complex Under Batch and Flow Conditions
0071
Suzuki–Miyaura Coupling of Nitrogen Heteroarenes by Pd-Ag Nanoclusters Decorated with Microcellulose
0072
Synthesis of β-Keto Sulfones Using g-C3N4 Under Blue LED Irradiation
0073
Hydroboration of Arylacetylenes by Ultrathin Imide-Linked Metal–Organic Framework Nanosheets

Organo- and Biocatalysis

z0075
All PDFs of this category
0075
Vitamin B2-Catalyzed Coupling of Sulfides and Alkenes
0076
Phenothiazine Photocatalyst Permits Copper-Free Bromoalkylation of Thianthrenium Salts
0077
Visible Light-Mediated β-Lactam Synthesis from Acryl Amide Precursors
0078
Bridged Tetrahydrobenzo[b]azepines/oxepines through Organocatalytic Aza-Piancatelli/Michael Reactions
0079
Stereoselective Multicomponent Synthesis of Alkaloid-Like Frameworks by Inverse Hydride Shuttle Catalysis
0080
Engineered Methyl Transferases Enable Regioselective N-Methylation of Unsaturated Heterocycles
0081
Enzymatic Amination and Amidation of Unactivated Csp3–H Sites
0082
Bifunctional Pyridoxal-Catalyzed Direct Enantioselective Synthesis of β-Aminoalcohols
0083
Organocatalytic Asymmetric Synthesis of SynVesT-1 and [18F]-SynVesT-1
0084
Catalytic Asymmetric Tautomerization of α-Hydroxy Ketones

Innovative Drug Discovery and Development

z0085
All PDFs of this category
0085
Photoaffinity Lipid Probes Decipher Docosahexanoic Acid Target
0086
The Power of Symmetry: Disorazole Z Analogues via a Double Stille Cross-Coupling
0087
Novel Dioxane- and Morpholino Nucleotide Analogues with Improved Off-Target Profiles in siRNAs
0088
Scalable Synthesis of a Fluorinated Bicyclic Pyrrolidinol
0090
Total Syntheses of Anthracimycin and Anthracimycin B
0091
PROCID: A Proximity-Based Drug Target-ID System
0092
Saxitoxin Structure–Activity Relationships Reveal Selective Inhibitors of NaV1.7
0093
T-Shaped Benzimidazole Platform for ER-Targeting Fluorophores
0094
Antiproliferative Effect of a Hybrid of Two Bistetrahydroisoquinoline Alkaloids
0095
Overcoming Antimicrobial Resistance: Rational Design of Rifamycin Antibiotics
0096
From Soil to Bench: Total Synthesis of Tigilanol Tiglate
0097
An Enantioenriched Synthesis of (S)-Ketamine

Peptide Chemistry

z0099
All PDFs of this category
0099
Ynamide-Mediated Peptide Synthesis
0100
Transfer Hydrogenation of α-Aryl Imino Esters for the Synthesis of α-Amino Acid Esters
0101
Cu-Catalyzed N–H Insertion of α-Alkyl-α-Diazo-acetates to Form N-Protected α-Alkyl Amino Esters
0102
Rh-Catalyzed Polyfluoroaryl Amino Acids Synthesis
0103
Synthesis of Glycopeptides Linked by Disulfide
0104
Rh-Catalyzed Three-Component Coupling Reaction to Form α,β-Tetrasubstituted Amino Acids
0105
Enantioselective Synthesis of α-Amino Acid Derivatives
0106
MgO-Mediated Synthesis of Fmoc-Protected Amino Acid Hydroxamates

Flow Chemistry

z0107
All PDFs of this category
0107
Benzophenone-Photocatalytic C4-Alkylation of Pyridinium Salts from C–H Bonds in Continuous Flow
0108
Flow-Type Switchable Oxidation to Form Carboxylic Acids and Aldehydes from Primary Alcohols

Erratum

0109
Tasker, N R; Wipf, P: Shortest Synthesis of Lysergol and its Binding to 5-HT1/2Receptors