Download PDF
Synfacts 2023; 19(01): 0099
DOI: 10.1055/s-0042-1752372
Peptide Chemistry

Ynamide-Mediated Peptide Synthesis

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori
Xu S, Jiang D, Peng Z, Hu L, *, Liu T, Zhao L, *, Zhao J. * Guangzhou Medical University and Nanjing Tech University, P. R. of China
Ynamide-Mediated Peptide Bond Formation: Mechanistic Study and Synthetic Applications.

Angew. Chem. Int. Ed. 2022;
61: e202212247
CrossrefPubMedSearch in Google Scholar
› Further Information
 
 PDF Download Permissions and Reprints

Key words

ynamides - cyclization - N-methylyne-methanesulfonamide

Significance

The development of promising coupling reagents is important, especially methods that can be used for amino acids that have a reactive functional group, even such as a hydroxyl group, without protecting it. The authors have developed an ynamide-mediated peptide-bond formation.


#

Comment

The ynamides were smoothly formed in the present of N-methylynemethanesulfonamide. The ynamides could be used as excellent substrates for peptide-bond formation. Furthermore, the system could be applied to the peptide cyclization.


#
#

Publication History

Article published online:
16 December 2022

© 2022. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany


   Permissions and Reprints