Xu S,
Jiang D,
Peng Z,
Hu L,
*,
Liu T,
Zhao L,
*,
Zhao J.
*
Guangzhou Medical University and Nanjing Tech University, P. R. of China
Ynamide-Mediated Peptide Bond Formation: Mechanistic Study and Synthetic Applications.
Angew. Chem. Int. Ed. 2022;
61: e202212247
DOI:
10.1002/anie.202212247
Key words
ynamides - cyclization -
N-methylyne-methanesulfonamide
Significance
The development of promising coupling reagents is important, especially methods that can be used for amino acids that have a reactive functional group, even such as a hydroxyl group, without protecting it. The authors have developed an ynamide-mediated peptide-bond formation.
Comment
The ynamides were smoothly formed in the present of N-methylynemethanesulfonamide. The ynamides could be used as excellent substrates for peptide-bond formation. Furthermore, the system could be applied to the peptide cyclization.
