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Synfacts 2024; 20(02): 0211
DOI: 10.1055/s-0043-1763667
Peptide Chemistry

Atom-Economical N-to-C Peptide Elongation

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori
Tatsumi T, Sasamoto K, Matsumoto T, Hirano R, Oikawa K, Nakano M, Yoshida M, Oisaki K, *, Kanai M. * The University of Tokyo and National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan
Practical N-to-C Peptide Synthesis with Minimal Protecting Groups.

Commun. Chem. 2023;
6: 231
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Key words

N-to-C peptide elongation - atom economy - nonapeptide synthesis

Significance

With growing applications of peptides, the development of efficient and atom-economical methods for their synthesis is highly desirable. The authors have demonstrated a sequence peptide elongation using unprotected amino acids or peptides with low waste.


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Comment

The peptide synthesis, which proceed by N-to-C elongation, is performed in an atom-economical way and the only wastes produced are water and elemental sulfur. Furthermore, the strategy could be applied for nonapeptide synthesis.


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Publication History

Article published online:
16 January 2024

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