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Synfacts 2024; 20(02): 0211
DOI: 10.1055/s-0043-1763667
DOI: 10.1055/s-0043-1763667
Peptide Chemistry
Atom-Economical N-to-C Peptide Elongation
Tatsumi T,
Sasamoto K,
Matsumoto T,
Hirano R,
Oikawa K,
Nakano M,
Yoshida M,
Oisaki K,
*,
Kanai M.
*
The University of Tokyo and National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan
Practical N-to-C Peptide Synthesis with Minimal Protecting Groups.
Commun. Chem. 2023;
6: 231
DOI: 10.1038/s42004-023-01030-0.
Practical N-to-C Peptide Synthesis with Minimal Protecting Groups.
Commun. Chem. 2023;
6: 231
DOI: 10.1038/s42004-023-01030-0.
Significance
With growing applications of peptides, the development of efficient and atom-economical methods for their synthesis is highly desirable. The authors have demonstrated a sequence peptide elongation using unprotected amino acids or peptides with low waste.
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Comment
The peptide synthesis, which proceed by N-to-C elongation, is performed in an atom-economical way and the only wastes produced are water and elemental sulfur. Furthermore, the strategy could be applied for nonapeptide synthesis.
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Publication History
Article published online:
16 January 2024
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