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Synfacts 2024; 20(03): 0332
DOI: 10.1055/s-0043-1773014
Peptide Chemistry

Palladium-Catalyzed Cross-Coupling for the Synthesis of Pyridyl Amino Acids

Contributor(s):
Hisashi Yamamoto
,
Isai Ramakrishna
Tabanella S, Valancogne I, Jackson RF. W. * The University of Sheffield, UK
Preparation of Enantiomerically Pure Pyridyl Amino Acids from Serine.

Org. Biomol. Chem. 2003;
1: 4254-4261
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Key words

palladium catalysis - pyridyl amino acids - serine - organozinc reagent

Significance

Pyridyl amino acids are the crucial building blocks for the synthesis of many bioactive molecules and play a significant role in chemical ­biology. In 2003, the authors developed a palladium-catalyzed cross-coupling of serine-derived organo­zinc reagents with halo-substituted pyridines for the synthesis of pyridyl amino acids.


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Comment

A series of pyridyl amino acids was synthesized by palladium-catalyzed cross-coupling of serine-derived organozinc reagents with halo-substituted pyridine.


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Publication History

Article published online:
14 February 2024

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