Zhuang K,
Haug GC,
Wang Y,
Yin S,
Sun H,
Huang S,
Trevino R,
Shen K,
Sun Y,
Huang C,
Qin B,
Liu Y,
Cheng M,
Larionov OV,
*,
Jin S.
*
University of Texas at San Antonio, USA and Shenyang Pharmaceutical University, P.
R. of China
Cobalt-Catalyzed Carbon–Heteroatom Transfer Enables Regioselective Tricomponent 1,4-Carboamination.
J. Am. Chem. Soc. 2024;
146: 8508-8519
DOI:
10.1021/jacs.3c14828
Key words
allylamines - carboamination - cobalt catalysis - dienes - photoredox catalysis
Significance
Merging cobalt and acridine photoredox catalysis enables the decarboxylative coupling
of carboxylic acids with 1,3-dienes and aniline derivatives to access aromatic allylic
amines.
Comment
This protocol features a broad substrate scope, as also demonstrated by the modification
of complex molecules. The reaction can be performed under batch or continuous-flow
conditions.
