DOI: 10.1055/s-00000131

Synfacts

Issue 06 · Volume 20 · June 2024 DOI: 10.1055/s-014-59610

Synform

A087
Zanda, Matteo: SYNFORM ISSUE 2024/06

Synthesis of Natural Products

z0561
All PDFs of this category
0561
Total Synthesis of (±)-Rubriflordilactone A
0562
Total Synthesis of (±)-Pallamolide A
0563
Total Synthesis of Salarins A and C
0564
Synthesis of (–)-Aspersteroid A
0565
Synthesis of (–)-Higginsianin A
0566
Total Synthesis of (–)-Spirophylline C and (+)-Spirophylline D
0567
Total Synthesis of Ajmaline

Synthesis of Heterocycles

z0569
All PDFs of this category
0569
Efficient Chloroacetoxylation of Pyrrolidines and Piperidines
0570
Cross-Dehydrogenative Couplings to Access C4-Disubstituted Dihydroquinazolines
0571
Efficient Suzuki–Miyaura Coupling of Glutarimide Derivatives
0572
C–H Functionalization of Heteroaromatics with α-C–H Bond of THF Rings
0573
Enantioselective Synthesis of Dihydropyrans via Fe(III)-Catalyzed Hetero-Diels–Alder Reaction
0574
Synthesis of Spiro Heterocycles through a Three-Component Reaction
0575
Brønsted Acid-Mediated Intramolecular Cyclization of 1,3-Azadienes Derived from Imines
0576
Efficient, One-Pot Synthesis of 5,6-Dihydro[2,1-a]isoquinolines
0577
Solvent-Free Mechanochemical Elaboration of Pyrazine Derivatives
0578
Chelation-Assisted Oxidative 1,3-Aryl Migration α-Aryl Allylic Alcohols via Csp2−Csp3 σ-Bond Activation
0579
One-Pot Synthesis of Structurally Diverse Sulfurized/ Selenated 4-Aminopyrimidines
0580
Nitrogen to Carbon Swap in Pyridine Systems

Synthesis of Materials and Unnatural Products

z0581
All PDFs of this category
0581
Regioselectivity in Mechanochemistry
0582
Double-Decker Macrocycles
0583
Reversible Sulfur Exchange via SNAr
0584
Water-Degradable Copolymers
0585
Facile π‑Extension of Triphenylenes
0586
Double [7]Helicenes with Chiroptical Amplification
0587
α,ω-Functionalized Polydienes from Organoaluminum
0588
2,6-Naphthyridine Synthesis and its Conjugated Polymers
0589
Self-Assembly and Self-Templated Growth of Graphdiynes
0590
Room Temperature Suzuki–Miyaura Polymerizations
0591
Four-Component Assembling of Covalent Organic Frameworks
0592
B,N-Embedded Helicenes

Metals in Synthesis

z0593
All PDFs of this category
0593
Enantioselective Synthesis of Organoborons Enabled by Cyclopropene Ring Opening
0594
Nickel-Catalyzed Enantioselective 1,2-Carboboration of Alkenes to Access β-Chiral Alkylboronates
0595
Making Allylamines by 1,4-Carboamination of 1,3-Dienes under Dual Cobalt and Acridine Catalysis
0596
Copper-Catalyzed Synthesis of Phenols and Anilines
0597
Copper Catalyzed C–H Functionalization
0598
Visible-Light-Mediated Amination Using Iron Catalysis
0599
Light-Enabled Isomerization of Borylated 1,3-Dienes
0600
Photocatalyzed O- to S- Rearrangement of Cyclopropanols
0601
Copper-Catalyzed Electrophilic Hydroxylamination of Arylboronic Acids with a Hypervalent Iodine Reagent
0602
Synthesis of Si-Stereogenic Silanols via Pd-Catalyzed C–H Alkenylation
0603
Allylic Amine Synthesis Enabled by Rare-Earth-Catalyzed Annulations
0604
Dynamic Kinetic Resolution of Racemic 2-Substituted Indoles by Pd-Catalyzed Asymmetric Hydrogenation
0605
A Metal-Catalyzed Functional Group Exchange Approach to Carbon-Labeled Carboxylic Acids
0606
Copper-Catalyzed Asymmetric Aminative Difunctionalization of Alkenes with Azodicarboxylates
0607
Stereoselective Synthesis of Chiral Cyclohexylamine Derivatives via Photocatalyzed [4+2] Cycloaddition
0608
Copper-Catalyzed Enantioconvergent Propargylic Amination to Access Chiral α-Tertiary Amines
0609
Stereoselective Synthesis of C-Aryl Glycosides via Palladium-Catalyzed Heck Coupling
0610
Palladium-Catalyzed Asymmetric Intramolecular Addition of Vinyl Halides to Carbonyl Groups
0611
Asymmetric Reductive Carbocyclization of 1,6-Enynes Under Nickel Catalysis
0612
Synthesis of Dihydrofurans by Palladium-Catalyzed [3+2] Cycloaddition
0613
Enantioselective Copper-Catalyzed C–S Coupling via SH2
0614
Directed Regio- and Enantioselective Hydrofluorination of Alkenes Under Nickel Hydride Catalysis
0615
Selective C–H Oxidation Enabled by Manganese Catalysis
0616
Rapid Access to Novel Antimalarials by a Cross-Electrophile Coupling Oxidation Sequence
0617
Rhodium-Catalyzed C–H Carbonylation of Benzamides Using a CO Surrogate
0618
Aryl–Aryl Bond Formation via a Rhodium-Catalyzed Split Cross-Coupling Strategy

Polymer-Supported Synthesis

z0619
All PDFs of this category
0619
Iron-Catalyzed Aerobic Oxidation of Allylic C–H Bonds
0620
Cu@C2N-Catalyzed Transformations of Alkynes: Hydration and Glaser–Hay Coupling
0621
Enantioselective Michael Addition Using Ni(OAc)2−Chiral Covalent Organic Cage Complexes
0622
Ruthenium-Sulfide: A Sulfur-Resistant Catalyst for Selective Hydrogenation of S-Containing Quinolines
0623
Oxidative Amidation of Aldehydes with an N-Doped Carbon-Supported Ni Catalyst
0624
Cycloaddition of Epoxides and CO2 by Cobalt Porphyrin-Based Hypercrosslinked Ionic Polymers
0625
Platinum–Molybdenum Nanoparticles-Catalyzed Reductive Amination of Carboxylic Acids
0626
Photo-Induced Hydrophosphinylation Using Single-Atom Copper, Supported on Carbon Nitride
0627
Development of a Biomass-Derived Carbon Aerogel-Supported Cu(OTf)2 Catalyst
0628
Co-MOF-Catalyzed Dehydrogenative Borylation of Alkenes
0629
Photo-Induced Aldol Condensation of Furfurals with Surface-Modified CdS Quantum Dots
0630
A COF-Based Metallaphotocatalyst for C–P Bond Forming Cross-Coupling

Organo- and Biocatalysis

z0631
All PDFs of this category
0631
Cooperative Photoredox and Chiral Brønsted Acid Catalysis Permits Asymmetric [2π+2σ] Cycloaddition
0632
Efficient Asymmetric Syntheses of Chiral Imines with Multi-Stereocenters
0633
Light-Governed Chemoselectivity in Organocatalytic C(sp2)–X Couplings
0634
Cinchona Phosphinate-Catalyzed Desymmetrization of Sulfonimidamides
0635
Silylium Ions Catalyze the Regioselective and Diastereoselective Thiosilylation of C–C Multiple Bonds
0636
Pivalate Salt-Catalyzed, Bis(silyl)acetamide-Mediated Silylation of Terminal Alkynes
0637
Harnessing N-Heterocyclic Carbene Catalytic Activity into Stereoselective Synthesis of Chiral Cyclophanes
0638
Photoenzymatic Hydroalkylation of Olefins toward Chiral α‑Chloroamides
0639
Organophotocatalytic Construction of Sulfonamides from Dibenzothiophenium Salts
0640
Potassium-ACDC of the Wittig Reaction

Innovative Drug Discovery and Development

z0641
All PDFs of this category
0641
A Non-Classical Linker for the Synthesis of a PROTAC
0642
[18F]4-Fluoro-4-deoxyfructose for Tracing of Fructose Metabolism
0643
Reproducibility Study of Surfactants Across Different Reaction Types
0644
SuFEx-Clickable Probe Against HIV-1 Capsid Protein
0645
Two-Step, One-Pot Annulation of Heteroarenes
0646
[3+2] Cycloaddition Approach to Difluoromethyl Isoxazoline Derivatives
0647
Large-Scale Asymmetric Synthesis of Spirocyclic Building Blocks for Drug Development
0648
Chemoenzymatic Synthesis Enables Decagram- and Gram-Scale Preparation of Prostaglandins
0649
(Chloromethyl)triisopropoxysilane Enables Highly Regioselective N1-Methylation of Pyrazoles
0650
Transition Metal-Free Synthesis of Hydrazides from Amides and Amines
0651
Structurally Simplified Natural Product Analogs Retain Bioactivity
0652
ABBP Uncovers a New Covalent ERCC Degrader from Spirocyclic Azetidines
0653
Synthesis and Biological Evaluation of a Voltage-Gated Sodium Channel Inhibitor
0654
Intermolecular Chalcogen Bonding between Galectin-3 and an Orally Bioavailable Antagonist

Peptide Chemistry

z0655
All PDFs of this category
0655
Synthesis of Peptides Inversely via the Utility of Transient Protected Amino Acids
0656
5- and 6-Membered Heteroaromatics-Embedded Amino Acids Synthesis via Electrochemical Means
0657
Visible-Light-Catalyzed Chemo-Selective β-C(sp3)–H Perfluoroarylation of Serine-Containing Peptides
0658
Synthesis of Amino Acid Based Chiral Cyclic Carbonates
0659
Near-IR-Induced Site-Selective Fluoroalkylation of Tryptophan and Tryptophan-Containing Peptides
0660
Selective S- and N-Acylation of Glutathione Using N-Acyl Imidazole
0661
gem-Difluorinated Cyclopropanes for α-Fluoro-allylation of Enantioselective Amino Acid Esters
0662
Improved Synthesis of Sensitive Peptides via Fmoc Deprotection Approach
0663
A Highly Diastereoselective Tandem Oxyhomologation–Coupling Method to Synthesize Amides and Peptides
0664
Visible-Light-Mediated β-Amino Acid Synthesis from α-Amino Acids
0665
gem-Difluoroallylation of Glycine and Glycine Residue in Peptides Using Organophotoredox Catalysis
0666
Chemoselective Photocatalytic Desulfonylation of Tryptophan Based Peptides
0667
CBMIT-Mediated Synthesis of Amino Esters and Peptides

Flow Chemistry

z0669
All PDFs of this category
0669
Norrish-Type Photocyclization of Aryl Triazines in Flow
0670
Continuous-Flow Process Enables Safe, Practical Access to Pharmaceutically Important 1,2,3-Triazole