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Synfacts 2024; 20(06): 0595
DOI: 10.1055/s-0043-1773281
Metals in Synthesis

Making Allylamines by 1,4-Carboamination of 1,3-Dienes under Dual Cobalt and Acridine Catalysis

Contributor(s):
Martin Oestreich
,
Hendrik F. T. Klare
,
Phillip Pommerening
Zhuang K, Haug GC, Wang Y, Yin S, Sun H, Huang S, Trevino R, Shen K, Sun Y, Huang C, Qin B, Liu Y, Cheng M, Larionov OV, *, Jin S. * University of Texas at San Antonio, USA and Shenyang Pharmaceutical University, P. R. of China
Cobalt-Catalyzed Carbon–Heteroatom Transfer Enables Regioselective Tricomponent 1,4-Carboamination.

J. Am. Chem. Soc. 2024;
146: 8508-8519
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Key words

allylamines - carboamination - cobalt catalysis - dienes - photoredox catalysis

Significance

Merging cobalt and acridine photoredox catalysis enables the decarboxylative coupling of carboxylic acids with 1,3-dienes and aniline derivatives to access aromatic allylic amines.


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Comment

This protocol features a broad substrate scope, as also demonstrated by the modification of complex molecules. The reaction can be performed under batch or continuous-flow conditions.


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Publication History

Article published online:
14 May 2024

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