Synthesis of Peptides Inversely via the Utility of Transient Protected Amino Acids

Key words

inverse peptide synthesis - transient protected amino acids - ynamide coupling

Significance

The rapid renaissance of peptide drugs in recent decades has made it incumbent on organic chemists to develop more efficient methods of peptide synthesis in terms of atom-economy in a green environment compared to the conventional methods as showcased by the authors of this work.

Comment

The various peptides were synthesized inversely in high yields and without racemization and epimerization from their respective carboxyl and amino donors through activation, transient protection, aminolysis and in situ deprotection ­using ynamide coupling reagent.

Publication History

Article published online:
14 May 2024