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Synfacts 2024; 20(06): 0667
DOI: 10.1055/s-0043-1763763
Peptide Chemistry

CBMIT-Mediated Synthesis of Amino Esters and Peptides

Contributor(s):
Hisashi Yamamoto
,
Isai Ramakrishna
Saha AK, Schultz P, Rapoport H. * University of California, Berkeley, USA
1,1'-Carbonylbis(3-methylimidazolium) Triflate: An Efficient Reagent for Aminoacylations.

J. Am. Chem. Soc. 1989;
111: 4856-4859
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Key words

CDI - 1,1'-carbonylbis(3-methylimidazolium) triflate - amino acid esters - peptide synthesis

Significance

The development of new coupling reagents for the synthesis of amino esters and peptides is highly demanded in organic synthesis. In 1989, the authors invented 1,1'-carbonylbis-(3-methylimidazolium) triflate as an efficient ­reagent for the synthesis of amino esters and ­peptides.


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Comment

A series of amino esters and peptides were synthesized with the aid of 1,1'-carbonylbis(3-methylimidazolium) triflate as the coupling agent. The reaction protocol is simple and proceeds without loss of optical purity.


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Publication History

Article published online:
14 May 2024

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