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Synfacts 2024; 20(07): 0767
DOI: 10.1055/s-0043-1774895
DOI: 10.1055/s-0043-1774895
Peptide Chemistry
Utilizing Proline Surrogates in the Synthesis of ‘Difficult’ Peptides
Wang X,
Jin K.
*
Shandong University, Jinan, P. R. of China
Robust Chemical Synthesis of “Difficult Peptides” via 2-Hydroxyphenol-pseudoproline (ψ2-hydroxyphenolpro) Modifications.
J. Org. Chem. 2024;
89: 3143-3149
DOI: 10.1021/acs.joc.3c02576.
Robust Chemical Synthesis of “Difficult Peptides” via 2-Hydroxyphenol-pseudoproline (ψ2-hydroxyphenolpro) Modifications.
J. Org. Chem. 2024;
89: 3143-3149
DOI: 10.1021/acs.joc.3c02576.
Significance
The synthesis of complex peptides with sequences that readily aggregate remains a huge challenge even with conventional methods. Herein, the authors report an efficient strategy to access them.
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Comment
A variety of novel 2-(oxazolidine-2-yl)phenol compounds were produced as proline surrogates and utilized in accessing ‘difficult’ peptides such as thymosin α1.
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Publikationsverlauf
Artikel online veröffentlicht:
14. Juni 2024
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