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DOI: 10.1055/s-0043-1774928
Ruthenium Chloride Catalyzed One-Pot Synthesis of Aldehydes Directly from Benzylic or Primary Alkyl Halides in Aqueous Medium
The authors acknowledge financial support from the Science and Engineering Research Board, India in the form of a Core Research Grant (No. CRG/2022/006324). Kiran acknowledges NIT Kurukshetra for financial support in the form of a fellowship.
Abstract
We report the first example of an acid- and oxidant-free one-pot conversion of benzylic or primary alkyl halides into aldehydes by using simple ruthenium chloride as the catalyst. The developed synthetic strategy is pot-economical and is also cheap as it uses hexamethylenetetramine as a reagent, employs as little as 0.5 mol% of ruthenium chloride, and efficiently converts the benzylic or primary alkyl halides into aldehydes in aqueous medium. The methodology was also found to be highly selective, as it forms the aldehyde product exclusively without forming possible byproducts, namely amines or carboxylic acids. The methodology is also superior in comparison with the conventional Sommelet and Kornblum oxidation reactions as it avoids the use of excess acid or DMSO, and uses very cheap and ecofriendly hexamethylenetetramine as both the formylating agent and base. The recyclability of the developed catalyst system was also tested, and showed excellent activities for up to three cycles.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1774928.
- Supporting Information
Publication History
Received: 16 May 2024
Accepted after revision: 08 June 2024
Article published online:
21 June 2024
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- 17 Oxidation of Primary Alkyl or Benzylic Halides; General Procedure The appropriate halide (0.42 mmol) was added to a Schlenk tube containing RuCl3·nH2O (0.5 mg, 0.5 mol%) and HMTA (0.0588 g, 0.42 mmol). H2O (0.6 ml) was then added and the resultant mixture was refluxed for 2 h until the reaction was complete (TLC). The product was extracted with CHCl3. Dodecane was added as an internal standard, and the mixture was filtered through Celite before injection into a gas chromatograph. For large-scale experiments, the isolated product was purified by short-column chromatography (silica gel, hexane–EtOAc).
- 18 Cinnamaldehyde; Gram-Scale Synthesis 3-Bromo-1-phenylprop-1-ene (5 mmol) was added to a Schlenk tube containing RuCl3·nH2O (6 mg, 0.5 mol%) and HMTA (0.7 g, 1 equiv). H2O (2 mL) was then added and the resultant mixture was refluxed for 2 h until the reaction was complete (TLC). The product was extracted with CHCl3 (3 × 10 mL) and the extracts were purified by column chromatography (silica gel, hexane–EtOAc) to give a yellow liquid; yield: 0.85 g (84%). 1H NMR (500 MHz, CDCl3): δ = 9.76 (s, 1 H), 7.44–7.47 (m, 4 H), 7.40–7.60 (m, 2 H), 6.70–6.76 (m, 1 H).
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