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Synfacts 2024; 20(09): 1007
DOI: 10.1055/s-0043-1774968
DOI: 10.1055/s-0043-1774968
Peptide Chemistry
O-Hydroxybenzenesulfonyl Chloride Mediated Peptide Synthesis
Cabaret D,
Wakselman M.
CNRS-CERCOA, Thiais, France
A Low-Epimerizing Peptide Coupling Reagent Based on the Rearrangement of a Carboxylic-Sulfonic Mixed Anhydride.
Tetrahedron Lett. 1994;
35: 9561-9564
DOI: 10.1016/0040-4039(94)88511-7.
A Low-Epimerizing Peptide Coupling Reagent Based on the Rearrangement of a Carboxylic-Sulfonic Mixed Anhydride.
Tetrahedron Lett. 1994;
35: 9561-9564
DOI: 10.1016/0040-4039(94)88511-7.
Key words
peptide synthesis - ortho-hydroxy-benzenesulfonyl chloride - coupling reagent - carboxylic-sulfonic mixed anhydride
Significance
The development of an easily accessible and inexpensive coupling reagent for peptide synthesis is a highly demanding area of organic synthesis. In this study, the authors found that suitably substituted ortho-hydroxybenzenesulfonyl chloride is efficient for the synthesis of peptides.
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Comment
A series of peptides were prepared with the help of ortho-hydroxybenzenesulfonyl chloride. The reaction is practically simple, the reaction proceeded with low epimerization with excellent yields.
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Publication History
Article published online:
16 August 2024
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