N-Methylated Peptide Synthesis Using Flow Chemistry

Key words

N-methylated peptides - flow chemistry - epimerization - Brønsted acids - mixed anhydrides

Significance

N-Methylated peptides are important in organic synthesis. The authors disclosed a method for synthesizing C-terminus-free N-methylated peptides in a micro-flow reactor. Unexpected C-terminal epimerization of the peptides was also observed.

Comment

The authors investigated the effect of Brønsted acids towards the activation of mixed carbonic anhydride using flow chemistry for the synthesis of C-terminus-free N-methylated peptides which is limited up to dipeptides.

Publication History

Article published online:
16 August 2024