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Synfacts 2024; 20(09): 0995
DOI: 10.1055/s-0043-1774974
DOI: 10.1055/s-0043-1774974
Peptide Chemistry
N-Methylated Peptide Synthesis Using Flow Chemistry
Chen T.-H,
Ando A,
Shamato O,
Fuse S.
*
Nagoya University, Japan
Effect of Brønsted Acids on the Activation of Mixed Anhydride/Mixed Carbonic Anhydride and C-Terminal-Free N-Methylated Peptide Synthesis in a Micro-Flow Reactor.
Chem. Eur. J. 2024;
30: e202401402
DOI: 10.1002/chem.202401402.
Effect of Brønsted Acids on the Activation of Mixed Anhydride/Mixed Carbonic Anhydride and C-Terminal-Free N-Methylated Peptide Synthesis in a Micro-Flow Reactor.
Chem. Eur. J. 2024;
30: e202401402
DOI: 10.1002/chem.202401402.
Key words
N-methylated peptides - flow chemistry - epimerization - Brønsted acids - mixed anhydrides
Significance
N-Methylated peptides are important in organic synthesis. The authors disclosed a method for synthesizing C-terminus-free N-methylated peptides in a micro-flow reactor. Unexpected C-terminal epimerization of the peptides was also observed.
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Comment
The authors investigated the effect of Brønsted acids towards the activation of mixed carbonic anhydride using flow chemistry for the synthesis of C-terminus-free N-methylated peptides which is limited up to dipeptides.
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Publication History
Article published online:
16 August 2024
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