^FCDMT-Mediated Peptide Synthesis

Key words

2-chloro-4,6-bis[(heptadecafluoro-nonyl)oxy]-1,3,5-triazine - peptide synthesis - fluorous coupling reagents

Significance

Development of eco-friendly, cost-effective, and practically easy coupling reagents for peptide synthesis is a highly demanding area of peptide drugs discovery. In this study, the authors invented 2-chloro-4,6-bis[(heptadecafluoro-nonyl)oxy]-1,3,5-triazine as an efficient coupling reagent for the synthesis of various peptides.

Comment

Various peptides were synthesized by the coupling between N-benzyloxycarbonyl amino acids and amino acid methyl esters with the help of 2-chloro-4,6-bis[(heptadecafluorononyl)oxy]-1,3,5-triazine. The protocol is practically simple and suitable for the synthesis of peptides having ­sterically hindered α,α-disubstituted amino acids.

Publikationsverlauf

Artikel online veröffentlicht:
16. Oktober 2024