Disease-Based Prognostication: Neuro-Oncology

Kristin A. Waite; Gino Cioffi; Mark G. Malkin; Jill S. Barnholtz-Sloan

doi:10.1055/s-0043-1775751

Seminars in Neurology, Table of Contents

Semin Neurol 2023; 43(05): 768-775
DOI: 10.1055/s-0043-1775751

Review Article

Disease-Based Prognostication: Neuro-Oncology

Kristin A. Waite^*

¹Division of Cancer Epidemiology and Genetics, Trans-Divisional Research Program, National Cancer Institute, Bethesda, Maryland

²Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, Illinois

,

Gino Cioffi^*

¹Division of Cancer Epidemiology and Genetics, Trans-Divisional Research Program, National Cancer Institute, Bethesda, Maryland

²Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, Illinois

,

Mark G. Malkin^**

³Cleveland Clinic, Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland, Ohio

,

Jill S. Barnholtz-Sloan^**

¹Division of Cancer Epidemiology and Genetics, Trans-Divisional Research Program, National Cancer Institute, Bethesda, Maryland

²Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, Illinois

⁴Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, Maryland

› Author Affiliations

Abstract

Primary malignant and non-malignant brain and other central nervous system (CNS) tumors, while relatively rare, are a disproportionate source of morbidity and mortality. Here we provide a brief overview of approaches to modeling important clinical outcomes, such as overall survival, that are critical for clinical care. Because there are a large number of histologically distinct types of primary malignant and non-malignant brain and other CNS tumors, this chapter will provide an overview of prognostication considerations on the most common primary non-malignant brain tumor, meningioma, and the most common primary malignant brain tumor, glioblastoma. In addition, information on nomograms and how they can be used as individualized prognostication tools by clinicians to counsel patients and their families regarding treatment, follow-up, and prognosis is described. The current state of nomograms for meningiomas and glioblastomas are also provided.

Keywords

meningioma - glioblastoma - clinical outcomes - nomogram - biomarkers

Full Text

References

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