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DOI: 10.1055/s-2001-11497
© Georg Thieme Verlag Stuttgart · New York
Essential Oils and Hexane Extracts from Leaves and Fruits of Cistus monspeliensis. Cytotoxic Activity of ent-13-epi-Manoyl Oxide and its Isomers
Publication History
March 7, 2000
May 31, 2000
Publication Date:
31 December 2001 (online)
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Abstract
Essential oils and hexane extracts from Cistus monspeliensis L. leaves and fruits were analysed by GC-MS. Manoyl oxide and its isomers, 3β-hydroxy-manoyl oxide, 3β-hydroxy-13-epi-manoyl oxide, as well as 3β-acetoxy-13-epi-manoyl oxide were detected for the first time in C. monspeliensis L. Ent-13-epi-manoyl oxide was isolated from the hexane extract of leaves and its structure was determined using spectroscopic methods. In vitro cytotoxic activity of ent-13-epi-manoyl oxide and mixtures of manoyl oxide isomers at 10-4 M concentrations ranged from 11.1 to 32.2 % of the activity for a vinblastine control evaluated against nine leukemic cell lines. The results showed that the manoyl oxide isomer mixtures as well as ent-13-epi-manoyl oxide exhibited a slight growth inhibiting activity.
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Ass. Prof. Dr. Costas Demetzos
School of Pharmacy
Department of Pharmacognosy
Panepistimiopolis Zografou 15771
Athens
Greece
Email: demetzos@galenos.pharm.uoa.gr
Fax: +30-1-7274596