Conversion of Imines into C,N-Dimagnesiated Compounds and Trapping with Electrophiles. One-Pot Access to 1-Azaspirocyclic Framework

Abstract

Under selected conditions, the Zr-catalyzed reaction of EtMgCl with imines produces C,N-dimagnesiated compounds, which can be further trapped with electrophiles. The overall transformation provides a new route to bifunctional or cyclic nitrogen-containing compounds. Particularly, 1-azaspirocyclic γ-lactams, pyrrolidines and azetidines can be obtained in this way.

azetidines - Grignard reagents - imines - spiro compounds - zirconium

References

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