Synlett 2002(11): 1889-1891
DOI: 10.1055/s-2002-34886
LETTER
© Georg Thieme Verlag Stuttgart · New York

A New Synthesis of 3-Substituted Pyrrolidines Using Iron Catalysed Cross-coupling Reactions and Ring Closing Metathesis

Niels Østergaarda,b, Brian Thoning Pedersena, Niels Skjærbækb, Per Vedsøa,, Mikael Begtrup*a
a Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, 2100 Copenhagen, Denmark
Fax: +4535306040; e-Mail: begtrup@dfh.dk;
b ACADIA Pharmaceuticals A/S, Fabriksparken 58, 2600 Glostrup, Denmark
Further Information

Publication History

Received 12 August 2002
Publication Date:
21 October 2002 (online)

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Abstract

A series of 3-substituted N-Boc protected pyrrolidines have been prepared via iron catalysed cross-coupling between Boc protected N-allyl-N-(2-bromoallyl)amine 3 and organomagnesium compounds followed by ring closing metathesis and subsequent hydrogenation of the formed pyrrolines.