An unusual but efficient method for the synthesis of phosphoroheterocycles,
1,3,2-thiazaphospholidine-4-thione 2-sulfide derivatives, by the
reaction of Lawesson’s reagent with a variety of α-hydroxy
nitriles has been developed. The possible mechanism of the reaction
is proposed to involve thiation of hydroxy group in a first step,
sequential addition of P-SH to the nitrile and rearrangement
resulting in the title phosphoroheterocycles. The preliminary bioassays
show that these heterocyclic compounds have herbicidal properties.
Lawesson’s reagent - α-hydroxynitriles - 1,3,2-thiazaphospholidine-4-thione 2-sulfide - herbicidal
activity
