Dutch Resolution: Separation of Enantiomers with Families of Resolving Agents. A Status Report

Richard M. Kellogg; José W. Nieuwenhuijzen; K. Pouwer; Ton R. Vries; Quirinus B. Broxterman; Reinier F. P. Grimbergen; Bernard Kaptein; René M. La Crois; Ellen de Wever; Karen Zwaagstra; Alexander C. van der Laan

doi:10.1055/s-2003-40508

FEATUREARTICLE

Dutch Resolution: Separation of Enantiomers with Families of Resolving Agents. A Status Report

Richard M. Kellogg*^a, José W. Nieuwenhuijzen^a, K. Pouwer^a, Ton R. Vries^a, Quirinus B. Broxterman^b, Reinier F.P. Grimbergen, Bernard Kaptein^b, René M. La Crois^a, Ellen de Wever^a, Karen Zwaagstra^a, Alexander C. van der Laan^a
^a Syncom B.V., Kadijk 3, 9747 AT Groningen, The Netherlands
Fax: +31(50)5757399; e-Mail: r.m.kellogg@syncom.nl;
^b DSM Research, Advanced Synthesis and Catalysis, PO Box 18, 6160 MD Geleen, The Netherlands

Abstract

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Abstract

Dutch Resolution is the term given to the use of mixtures (families) of resolving agents in classical resolutions. In this status report an overview is given of the latest results and new (possible) families of resolving agents are introduced. The concept of families is discussed as well as the factors that come into play on use of families. Practical aspects of Dutch Resolution in particular and resolutions in general are discussed.

Key words

amino alcohols - asymmetric synthesis - chiral auxiliaries - chiral resolution - chirality - camphor - chalcones - sulfonic acids

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References

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6c