Synlett 2003(10): 1542-1544
DOI: 10.1055/s-2003-40845
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Convenient Synthetic Routes to 5-Substituted 3-(4-Methoxyphenyl)-4(1H)-quinolones

Benoît Joseph*a,b, Aurélie Béhardb, Brigitte Lesurc, Gérald Guillaumetb
a Laboratoire de Chimie Organique 1, UMR-CNRS 5622, Université Claude Bernard - Lyon 1, CPE - Bâtiment 308, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
Fax: +33(4)72431214; e-Mail: benoit.joseph@univ-lyon1.fr;
b Institut de Chimie Organique et Analytique, UMR-CNRS 6005, Université d’Orléans, B.P. 6759, 45067 Orléans Cedex 2, France
c Cephalon France, Centre de Recherche et de Développement, 19 Avenue du Professeur Cadiot, 94701 Maisons-Alfort Cedex, France
Further Information

Publication History

Received 26 May 2003
Publication Date:
24 July 2003 (online)

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Abstract

5-Substituted 3-(4-methoxyphenyl)-4(1H)-quinolones 5-18 have been synthesised in good yields from the corresponding 3-(4-methoxyphenyl)-5-trifluoromethanesulfonate-4(1H)-quinolo-nes 4 via palladium-mediated cross-coupling reactions or aromatic nucleophilic substitution (SNAr) reactions.