Highly Diastereoselective Addition of Ketone Enolates to N-Sulfinyl Imines: Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohol Derivatives

Abstract

Lithium enolates derived from ketones may be added to N-sulfinyl imines with high diastereoselectivity. Diastereoselective reduction gave either the syn- or anti-1,3-amino alcohol derivative.

Key words

asymmetric synthesis - chiral auxiliaries - amino alcohols - stereoselective synthesis

References

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