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Synlett 2004(13): 2417-2420
DOI: 10.1055/s-2004-832826
DOI: 10.1055/s-2004-832826
CLUSTER
© Georg Thieme Verlag Stuttgart · New York
trans-1,2-Diaminocyclopentane-Based Catalyst for the Asymmetric Addition of Alkyl-, Aryl-, and Vinyl Groups to Ketones
Further Information
Publication History
Received
9 July 2004
Publication Date:
24 September 2004 (online)


Abstract
The catalytic asymmetric addition of ethyl-, phenyl-, and 1-hexenyl groups to ketones is reported. The new catalyst, generated from titanium isopropoxide and a bis(sulfonamide) diol ligand based on trans-1,2-diaminocyclopentane, gives good to excellent enantioselectivities with a range of substrates.
Key words
alcohols - asymmetric catalysis - ketones - quaternary centers - ligands