trans-1,2-Diaminocyclopentane-Based Catalyst for the Asymmetric Addition of Alkyl-, Aryl-, and Vinyl Groups to Ketones

Abstract

The catalytic asymmetric addition of ethyl-, phenyl-, and 1-hexenyl groups to ketones is reported. The new catalyst, generated from titanium isopropoxide and a bis(sulfonamide) diol ligand based on trans-1,2-diaminocyclopentane, gives good to excellent enantioselectivities with a range of substrates.

Key words

alcohols - asymmetric catalysis - ketones - quaternary centers - ligands

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