Abstract
The use of indium organometallics in multifold and sequential cross-coupling reactions is reported. Triorganoindium reagents (R3 In) react, under palladium catalysis, with oligohaloarenes affording the multiple cross-coupling products in a single operation. In the reaction, the three organic groups (alkyl, aryl, alkenyl or alkynyl) attached to indium are efficiently transferred to the electrophile, with only a slight excess of organometallic reagent. We demonstrate that indium organometallics are useful reagents for sequential cross-coupling reactions. This reaction illustrates the high chemoselectivity of R3 In.
1 Introduction
2 Results and Discussion
2.1 Multifold Cross-Coupling Reactions
2.2 Sequential Cross-Coupling Reactions
3 Conclusion
Key words
atom economy - indium - organometallic reagents - multifold and sequential cross-coupling - palladium catalysis
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