β-Cyclodextrin Columns for Separation of Fluorous and Non-Fluorous Compounds: How To Use β-Cyclodextrin Columns in Fluorous Mixture Synthesis and Racemic Synthesis

Abstract

Guidelines for the use of β-cyclodextrin columns in fluo­rous and non-fluorous mixture synthesis, and racemic synthesis are suggested. Fluorous compounds can be separated more efficiently with SUMICHIRAL OA-7000 and -7100, while non-fluorous compounds can be separated better with SUMICHIRAL OA-7500. When the ratio of water in the mobile phase is large (>20%), the guard column (GL cart) can improve the separability of the fluorinated mixture.

Key words

β-cyclodextrin - chromatography - combinatorial chemistry - fluorous mixture synthesis - racemic synthesis

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7

GL cart is commercially available from GL Sciences. URL of GL Sciences: http://www.gls.co.jp/

10

Mismatched compounds with fluorous or non-fluorous tags are now under investigation with OA-7000 and -7100, in particular.