Synthesis of Discodermolide Using Solely Substrate-Based Stereocontrol

I. Paterson; O. Delgado; G. J. Florence; I. Lyothier; M. O’Brien; J. P. Scott; N. Sereinig

doi:10.1055/s-2005-872154

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Synfacts 2005(1): 0101-0101
DOI: 10.1055/s-2005-872154

Synthesis of Natural Products and Potential Drugs

Synthesis of Discodermolide Using Solely Substrate-Based Stereocontrol

Contributor(s): Philip Kocienski
I. Paterson*, O. Delgado, G. J. Florence, I. Lyothier, M. O’Brien, J. P. Scott, N. Sereinig
University of Cambridge, UK

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Publication History

Publication Date:
21 September 2005 (online)

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Significance

(+)-Discodermolide is isolated from the Caribbean deep sea sponge Discodermia dissoluta. It exhibits immunosuppressive and cell growth inhibitory biological activity and is currently entering clinical trials.