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Synfacts 2005(1): 0109-0109
DOI: 10.1055/s-2005-872207
DOI: 10.1055/s-2005-872207
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
Regioselective Hydroamination for the Synthesis of Tricyclic Quinolines
C. S. Yi*, S. Y. Yun, I. A. Guzei
University of Wisconsin-Madison, USA
Further Information
Publication History
Publication Date:
21 September 2005 (online)
Significance
An efficient catalytic C-H bond activation/hydroamination protocol has been developed for the synthesis for tricyclic quinoline derivatives in modest to excellent yields (42-99%) under mild conditions. The reaction shows rapid attainment of complexity with minimum functional group requirement. A catalytically active cationic ruthenium-acetylide complex has been isolated and characterized but not shown to participate in the reaction.