Synthesis of (-)-Batzelladine D

M. A. Arnold; S. G. DurÓn; D. Y. Gin

doi:10.1055/s-2005-916049

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Synfacts 2005(2): 0193-0193
DOI: 10.1055/s-2005-916049

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Batzelladine D

Contributor(s): Philip Kocienski
M. A. Arnold, S. G. DurÓn, D. Y. Gin*
University Of Illinois, Urbana, USA

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Publication History

Publication Date:
25 October 2005 (online)

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Significance

Members of the Batzelladine family of marine alkaloids inhibit binding of HIV gp120 to human CD4 and induce protein kinase p56^lck dissociation from CD4.