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Synfacts 2005(3): 0297-0297  
DOI: 10.1055/s-2005-921584
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

[2+2+2] Cyclotrimerization to Benzofurans, Benzothiophenes and Isoindoles

Contributor(s): Victor Snieckus, Robert Engqvist
S. Saaby, I. R. Baxendale, S. V. Ley*
University of Cambridge, UK
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Publikationsdatum:
22. November 2005 (online)

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Significance

An intramolecular alkyne trimerization using microwave heating in both batch and flow systems is presented. The reaction proceeds under non-metal-catalyzed conditions in acceptable to good yields. A mechanism is proposed for the reaction which involves diradical intermediates.