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Synfacts 2005(3): 0276-0276  
DOI: 10.1055/s-2005-921589
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Brevetoxin B

Contributor(s): Philip Kocienski
I. Kadota*, H. Takamura, H. Nishii, Y. Yamamoto
Tohoku University, Japan
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Publication History

Publication Date:
22 November 2005 (online)

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Significance

Brevetoxin B is a potent neurotoxin isolated from Gymnodinium breve. Two previous syntheses of Brevetoxin B have been described by Nicolaou et al. (J. Am. Chem. Soc. 1995, 117, 10252-10263 and references therein) and by Matsuo et al. (J. Am. Chem. Soc. 2004, 126, 14374-14376). In the synthesis by Kadota and co-workers, the longest linear sequence was 63 steps (0.28% overall) and the total number of steps was 108.