Synthesis of an NK1 Receptor Antagonist

M. A. Huffman; J. H. Smitrovich; J. D. Rosen; G. N. Boice; C. Qu; T. D. Nelson; J. M. McNamara

doi:10.1055/s-2005-921599

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Synfacts 2005(3): 0281-0281
DOI: 10.1055/s-2005-921599

Synthesis of Natural Products and Potential Drugs

Synthesis of an NK₁ Receptor Antagonist

Contributor(s): Philip Kocienski
M. A. Huffman*, J. H. Smitrovich, J. D. Rosen, G. N. Boice, C. Qu, T. D. Nelson, J. M. McNamara
Merck & Co, Rayway, USA

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Publication History

Publication Date:
22 November 2005 (online)

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Significance

The binding of tachykinin substance P to the neurokinin-1 (NK₁) receptor is a key event in the onset of stress and inflammation. The tetrahydropyran G is a powerful NK₁ receptor antagonist.