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Synfacts 2005(3): 0327-0327  
DOI: 10.1055/s-2005-921629
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

A Mild Deoxygenation of Alcohols by Trialkylboranes-Air via Xanthate Esters

Contributor(s): Paul Knochel, Andrei Gavryushin
D. A. Spiegel, K. B. Wiberg, L. N. Schacherer, M. R. Medeiros, J. L. Wood*
Yale University, New Haven, USA
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Publication History

Publication Date:
22 November 2005 (online)

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Significance

This method offers a good alternative for metal hydrides in reductive deoxygenation. The procedure is very mild and especially suitable for applications in natural product synthesis. Besides, it is an excellent way for the introduction of a deuterium label in complex molecules using available and cheap D2O.