Highly Enantioselective Tandem Conjugate Thiol Addition-Amination Reaction

Significance

Asymmetric organocatalytic multicomponent reactions could be attractive to produce compounds with multiple stereogenic centers using simple and environmentally friendly processes. Here the first highly enantioselective organocatalytic multicomponent domino conjugate thiol addition-α-amination reaction forming enantiopure amino-thiols in moderate to good yields is described. The authors also report on an organocatalytic conjugate addition of thiols to α,β-unsaturated aldehydes with excellent yields and enantioselectivity.