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DOI: 10.1055/s-2006-926244
Preparation of the Neolignan Natural Product Grossamide by a Continuous-Flow Process
Publication History
Publication Date:
06 February 2006 (online)
Abstract
This article describes the first enantioselective total synthesis of 2-aryl-2,3-dihydro-3-benzofurancarboxyamide neolignan, grossamide (1) using a fully automated and scalable flow reactor.
Key words
polymer-supported reagents - enzymes - flow synthesis - natural products
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References
With DMF followed by THF.
9The exact amount was highly dependant on flow rates, scale and specific dimensions of the column. Optimum conditions could be rapidly determined in an automated screening fashion.
10The columns could be efficiently recycled up to five times before any noticeable decrease in reactivity was observed.