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Synfacts 2006(3): 0296-0296  
DOI: 10.1055/s-2006-932000
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Polymeric Palladium Catalyst for Cross-Coupling Reactions in Water

Contributor(s): Yasuhiro Uozumi, Ray Kawade, Toshimasa Suzuka
J. Gil-Moltó, S. Karlström, C. Nájera*
Universidad de Alicante, Spain
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Publication History

Publication Date:
21 February 2006 (online)

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Significance

A novel polymer-supported palladium-dipyridylmethylamine catalyst A was prepared from poly(styrene-alt-maleic anhydride) resin 1, di(pyrid-2-yl)methylamine (2) and Na2PdCl4. Its catalytic activity for several cross-coupling reactions such as Heck, Suzuki, and Sonogashira reactions in water was evaluated (Heck reaction: up to 104 TON; Suzuki coupling: up to 105 TON; Sonogashira reaction: up to 105 TON). Catalyst A can be recovered and reused several times without significant loss of the catalytic activity (89-99% yields).