Synlett 2006(9): 1413-1415  
DOI: 10.1055/s-2006-939729
LETTER
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Silyloxy-Cope Rearrangement of syn-Aldol Products in DMF: Enhancement of Rate and Diastereoselectivity

Christoph Schneider*, Souad Khaliel
Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany
Fax: +49(341)9736599; e-Mail: schneider@chemie.uni-leipzig.de;
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Publication History

Received 16 February 2006
Publication Date:
22 May 2006 (online)

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Abstract

Microwave-assisted Cope rearrangements of 1,5-dienes embedded in a syn-aldol structure proceed in substantially reduced reaction times and markedly increased diastereoselectivity when conducted in DMF as solvent.

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