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Synfacts 2006(7): 0691-0691
DOI: 10.1055/s-2006-941859
DOI: 10.1055/s-2006-941859
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Spiroborate Ether Mediated Enantioselective Reduction of Oxime Ethers
Y. Chu, Z. Shan*, D. Liu, N. Sun
Wuhan University, P. R. of China
Further Information
Publication History
Publication Date:
22 June 2006 (online)
Significance
In the present paper, the authors describe the borane reduction of oxime ethers mediated by a chiral tetracoordinated spiroborate ester. Enantioenriched secondary amines are accessed in excellent ee values and yields. This represents an alternative to reductions centered around catalysts based on complexes of Rh, Ir, Ru and Ti.