Pd(0)-Catalyzed Reduction of Aromatic Acid Chlorides to Aldehydes

Significance

This method is a further development of a previously published protocol of the acid chloride reduction in the presence of an organotin catalyst. Importantly, the authors have proven that a silane itself can be used as a reducing agent, thus avoiding the use of toxic tin compounds. The reaction proceeds at ambient temperature within an hour, and the yields are uniformly good. A halide substituent on the aryl ring remains intact during the reaction.