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Synfacts 2006(7): 0709-0709  
DOI: 10.1055/s-2006-941886
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

New Catalysts for Cross-Coupling of Heteroaryl Chlorides

Contributor(s): Paul Knochel, Andrei Gavryushin
A. S. Guram*, A. O. King, J. G. Allen, X. Wang, L. B. Schenkel, J. Chan, E. E. Bunel, M. M. Faul, R. D. Larsen, M. J. Martinelli, P. J. Reider
Amgen Inc., Thousand Oaks, USA
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Publication History

Publication Date:
22 June 2006 (online)

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Significance

The Suzuki-Miyaura reaction is extensively used for the construction of the carbon frameworks in the synthesis of biologically active molecules. This work describes a new highly general, easy to prepare and handle, and stable catalyst for this process. High activity was observed for common substrates (TON over 10000). The reaction proceeds well for a broad variety of hetero­aryl chlorides as well as for sterically hindered boronic acids.