Asymmetric Additions of Allyl- and Crotylboronates to Aldehydes

Significance

The allylation of carbonyls is a very important reaction for the synthesis of useful building blocks. While there are many allylation reagents and protocols, this report provides a broad scope of substrates and provides homoallylic alcohols with high selectivities (high er and dr). The use of the Lewis acid assisted Brønsted acid (LBA) system proved necessary for obtaining a fast and selective reaction. The addition of Na₂CO₃ was necessary for the scavenging of HCl (from SnCl₄).