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Synfacts 2006(9): 0914-0914  
DOI: 10.1055/s-2006-949243
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Addition of Dialkylzinc Reagents toα-Aldiminoesters

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
S. Basra, M. W. Fennie, M. C. Kozlowski*
University of Pennsylvania, Philadelphia, USA
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Publikationsdatum:
23. August 2006 (online)

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Significance

Enantioselective additions to the more challenging α-imino esters, giving rise to α-amino esters, are reported. The use of Ti instead of other metals was found to be slightly more beneficial. This represents the first enantioselective addition of Et2Zn to α-aldiminoesters.