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Synfacts 2006(9): 0925-0925  
DOI: 10.1055/s-2006-949246
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Regiochemical Controlled Transposition of Allylic Silyl Ethers

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
E. C. Hansen, D. Lee*
University of Wisconsin, Madison, USA
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Publication History

Publication Date:
23 August 2006 (online)

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Significance

Stereoselective [1,3]-transposition represents one of the most important synthetic transformations. Regio- and stereoselectivity as well as equilibrium issues always accompany this reaction and prevent efficient generation of the desired rearranged alcohol. This simple two-step protocol offers a powerful alternative to reach higher regioselectivity.